Neurodegenerative diseases and effective drug delivery: A review of challenges and novel therapeutics

The central nervous system (CNS) encompasses the brain and spinal cord is considered processing center most vital part of human body. barriers are crucial interfaces between CNS periphery. Among all these biological barriers, blood-brain barrier (BBB) strongly impede hurdle for drug transport to brain. It a semi-permeable diffusion against noxious chemicals harmful substances present in blood stream regulates nutrients delivery its proper functioning. Neurological diseases owing existence BBB blood-spinal have been terrible threatening challenges over world can rarely be directly mediated. In fact, remained challenge treatment neurodegenerative (ND) disorders, different approaches proposed. Nano-fabricated smart systems implantable loaded biomaterials repair among some latest approaches. current review, modern developed deal with associated transporting drugs included. Recent studies on neural discovery injectable hydrogels provide potential new option neurological disorders. Moreover, induced pluripotent stem cells used model ND discussed evaluate efficacy. These protocols recent developments will enable more effective